144 0001825445 XXXXXXXX LIVE 0001819133 TANGO THERAPEUTICS, INC. 001-39485 201 BROOKLINE AVENUE, SUITE 901 BOSTON MA 02215 8573204900 ADAM CRYSTAL Officer Common Morgan Stanley Smith Barney LLC Executive Financial Services

1 New York Plaza 8th Floor New York NY 10004

81000 2201580.00 144647982 08/03/2026 NASDAQ Common 08/03/2026 Exercise of Stock Options Issuer N 81000 08/03/2026 Cash N 10b5-1 Sales for ADAM CRYSTAL

201 BROOKLINE AVENUE, SUITE 901 BOSTON MA 02215

Common 07/01/2026 27000 798907.20 10b5-1 Sales for ADAM CRYSTAL

201 BROOKLINE AVENUE, SUITE 901 BOSTON MA 02215

Common 06/01/2026 27000 617571.00 The securities to be sold were and will be received upon the exercise of stock options over the next three months. The dates of acquisition and payment were and will be the dates of exercise/sale. 08/03/2026 10/27/2025 /s/ Adam Crystal