X0306 4 2023-03-02 0001299130 PACIFIC BIOSCIENCES OF CALIFORNIA, INC. PACB 0001825421 Kim Susan G. PACIFIC BIOSCIENCES OF CALIFORNIA, INC. 1305 O'BRIEN DRIVE MENLO PARK CA 94025 0 1 0 0 See Remarks Common Stock 2023-03-02 4 A 0 164200 0 A 328550 D Common Stock 2023-03-03 4 S 0 5045 9.493 D 323505 D Each share is represented by a Restricted Stock Unit ("RSU"). The RSUs will vest in equal annual installments on February 15th of each of 2024, 2025, 2026, and 2027, provided that the Reporting Person continues to serve through each applicable vesting date. Includes 1,769 shares purchased on March 1, 2023 under the Company's 2010 Employee Stock Purchase Plan. Represents the number of shares automatically sold to cover tax withholding obligations in connection with the vesting of restricted stock units. This sale price represents the weighted average sale price of the shares sold ranging from $9.24 to $9.71 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price within the range set forth in this Form 4. Chief Financial Officer /s/ Michele Farmer, Attorney-in-fact 2023-03-06