X0306 4 2022-09-29 0001299130 PACIFIC BIOSCIENCES OF CALIFORNIA, INC. PACB 0001825421 Kim Susan G. PACIFIC BIOSCIENCES OF CALIFORNIA, INC. 1305 O'BRIEN DRIVE MENLO PARK CA 94025 0 1 0 0 See Remarks Common Stock 2022-09-29 4 S 0 12968 5.614 D 163488 D Represents the number of shares automatically sold to cover tax withholding obligations in connection with the vesting of restricted stock units. This sale price represents the weighted average sale price of the shares sold ranging from $5.41 to $5.69 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price within the range set forth in this Form 4. Includes 1,490 shares purchased on September 1, 2021, March 1, 2022 and September 1, 2022 under the Company's 2010 Employee Stock Purchase Plan. Chief Financial Officer /s/ Michele Farmer, Attorney-in-fact 2022-10-03