SCHEDULE 13G 0001738048 XXXXXXXX LIVE Common Stock, $0.0001 par value per share 03/26/2025 0001824893 Surrozen, Inc. 86889P208 171 OYSTER POINT BLVD SUITE 400 SOUTH SAN FRANCISCO CA 94080 Rule 13d-1(c) Venrock Healthcare Capital Partners III, L.P. a DE 0.00 872546.00 0.00 872546.00 872546.00 9.9 PN VHCP Co-Investment Holdings III, LLC a DE 0.00 872546.00 0.00 872546.00 872546.00 9.9 OO Venrock Healthcare Capital Partners EG, L.P. a DE 0.00 872546.00 0.00 872546.00 872546.00 9.9 PN VHCP Management III, LLC a DE 0.00 872546.00 0.00 872546.00 872546.00 9.9 OO VHCP Management EG, LLC a DE 0.00 872546.00 0.00 872546.00 872546.00 9.9 OO Nimish Shah a X1 0.00 872546.00 0.00 872546.00 872546.00 9.9 IN Bong Y Koh a X1 0.00 872546.00 0.00 872546.00 872546.00 9.9 IN Surrozen, Inc. 171 OYSTER POINT BLVD, SUITE 400, SOUTH SAN FRANCISCO, CA, 94080. The names of the persons filing this report (collectively, the "Reporting Persons") are: Venrock Healthcare Capital Partners III, L.P. ("VHCP III") VHCP Co-Investment Holdings III, LLC ("VHCP Co-Investment III") Venrock Healthcare Capital Partners EG, L.P. ("VHCP EG") VHCP Management III, LLC ("VHCP Management III") VHCP Management EG, LLC ("VHCP Management EG") Nimish Shah ("Shah") Bong Koh ("Koh") The Reporting Persons are members of a group for the purposes of this Schedule 13G. New York Office: 7 Bryant Park, 23rd Floor New York, NY 10018 Palo Alto Office: 3340 Hillview Avenue Palo Alto, CA 94304 VHCP III Delaware Co-Investment III Delaware VHCP EG Delaware VHCP Management III Delaware VHCP Management EG Delaware Shah United States Koh United States Y Row 9 of each Reporting Person's cover page to this Schedule 13G sets forth the aggregate number of securities of the Issuer beneficially owned by such Reporting Person and is incorporated by reference. The Reporting Persons' ownership of the Issuer's securities consists of (i) 130,890 shares of common stock, pre-funded warrants (the "Pre-Funded Warrants") exercisable for up to 207,834 shares of common stock and common stock warrants (the "Series E Warrants") exercisable for up to 169,362 shares of common stock, in each case held by VHCP III; (ii) 13,102 shares of common stock, Pre-Funded Warrants exercisable for up to 20,804 shares of common stock and Series E Warrants exercisable for up to 16,953 shares of common stock, in each case held by VHCP Co-Investment III; and (iii) 488,939 shares of common stock, Pre-Funded Warrants exercisable for up to 776,362 shares of common stock and Series E Warrants exercisable for up to 632,650 shares of common stock, in each case held by VHCP EG. The Series E Warrants and Pre-Funded Warrants each contain a provision (the "Beneficial Ownership Blockers"), which precludes the exercise of the Series E Warrants and/or Pre-Funded Warrants to the extent that, following exercise, VHCP III, VHCP Co-Investment III and VHCP EG, together with their affiliates and other attribution parties, would own more than 9.99% of the common stock outstanding. Each of VHCP III, VHCP Co-Investment III and VHCP EG is currently prohibited from exercising the Series E Warrants or the Pre-Funded Warrants to the extent that such exercise would result in beneficial ownership of more than 872,546 shares of common stock. VHCP Management III is the general partner of VHCP III and the manager of VHCP Co-Investment III. VHCP Management EG is the general partner of VHCP EG. Messrs. Shah and Koh are the voting members of VHCP Management III and VHCP Management EG. Each Reporting Person beneficially owns 9.99% of the Issuer's common stock, which percentage is based upon the sum of (i) 3,281,169 shares of the Issuer's common stock outstanding as of March 25, 2025, as reported in the Issuer's Annual Report on Form 10-K filed with the Securities and Exchange Commission (the "SEC") on March 31, 2025; and (ii) 5,213,415 shares of the Issuer's common stock issued in the private placement of equity securities by the Issuer that closed on March 26, 2025, adjusted to give effect to the Series E Warrants and Pre-Funded Warrants, to the extent that such securities may be exercised within 60 days hereof, as referenced herein. Due to field limitations of the EDGAR filing system, the percentages listed in Row 11 of each Reporting Person's cover page have been rounded down to 9.9%. Row 5 of each Reporting Person's cover page to this Schedule 13G sets forth the sole power to vote or to direct the vote of securities of the Issuer beneficially owned by such Reporting Person and is incorporated by reference. Row 6 of each Reporting Person's cover page to this Schedule 13G sets forth the shared power to vote or to direct the vote of securities of the Issuer beneficially owned by such Reporting Person and is incorporated by reference. Row 7 of each Reporting Person's cover page to this Schedule 13G sets forth the sole power to dispose or to direct the disposition of securities of the Issuer beneficially owned by such Reporting Person and is incorporated by reference. Row 8 of each Reporting Person's cover page to this Schedule 13G sets forth the shared power to dispose or to direct the disposition of securities of the Issuer beneficially owned by such Reporting Person and is incorporated by reference. Y Y Y Y Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11. Exhibit 24.1 Power of Attorney for Bong Koh Exhibit 24.2 Power of Attorney for Nimish Shah Exhibit 99.1 Joint Filing Agreement Venrock Healthcare Capital Partners III, L.P. /s/ Sherman G. Souther 04/02/2025 VHCP Co-Investment Holdings III, LLC /s/ Sherman G. Souther 04/02/2025 Venrock Healthcare Capital Partners EG, L.P. /s/ Sherman G. Souther 04/02/2025 VHCP Management III, LLC /s/ Sherman G. Souther 04/02/2025 VHCP Management EG, LLC /s/ Sherman G. Souther 04/02/2025 Nimish Shah /s/ Sherman G. Souther 04/02/2025 Bong Y Koh /s/ Sherman G. Souther 04/02/2025