Exhibit 23.1

Consent of Independent Registered Public Accounting Firm

We consent to the incorporation by reference in the following Registration Statements:

(1)Registration Statement (Form S-8 No. 333-260858) pertaining to the 2015 Equity Incentive Plan, the 2021 Equity Incentive Plan and the 2021 Employee Stock Purchase Plan of Surrozen, Inc.;

(2)Registration Statement (Forms S-8 Nos. 333-271017 and 333-263924) pertaining to the 2021 Equity Incentive Plan and the 2021 Employee Stock Purchase Plan of Surrozen, Inc.; and

(3)Registration Statement (Form S-3 No. 333-268745) of Surrozen, Inc.;

of our report dated April 10, 2024, with respect to the consolidated financial statements of Surrozen, Inc. included in this Annual Report (Form 10-K) of Surrozen, Inc. for the year ended December 31, 2023.

/s/ Ernst & Young LLP

San Francisco, California

April 10, 2024