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                          April 1, 2022

       Craig Parker
       President and Chief Executive Officer
       Surrozen, Inc.
       171 Oyster Point Blvd, Suite 400
       South San Francisco, CA 94080

                                                        Re: Surrozen, Inc.
                                                            Registration
Statement on Form S-1
                                                            Filed March 29,
2022
                                                            File No. 333-263923

       Dear Mr. Parker:

              This is to advise you that we have not reviewed and will not
review your registration
       statement.

               Please refer to Rules 460 and 461 regarding requests for
acceleration. We remind you
       that the company and its management are responsible for the accuracy and
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of
action by the staff.

                                                        Please contact Tyler
Howes at 202-551-3370 with any questions.




                          Sincerely,


                          Division of Corporation Finance

                          Office of Life Sciences
       cc:                                              John T. McKenna, Esq.