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                              October 26, 2020

       Gad Soffer
       Chief Executive Officer
       Consonance-HFW Acquisition Corp.
       1 Palmer Square, Suite 305
       Princeton, NJ 08540

                                                        Re: Consonance-HFW
Acquisition Corp.
                                                            Amendment No. 2 to
Registration Statement on Form S-1
                                                            Filed October 26,
2020
                                                            File No. 333-249394

       Dear Mr. Soffer:

              We have reviewed your amended registration statement and have the
following
       comment. In our comment we may ask you to provide us information so that
we may better
       understand your disclosure.

              Please respond to this letter by amending your registration
statement and providing the
       requested information. If you do not believe that our comment applies to
your facts and
       circumstances or do not believe that an amendment is appropriate, please
tell us why in your
       response.

              After reviewing any amendment to your registration statement and
the information that
       you provide in response to the comment, we may have additional comments.

       Amendment No. 2 to Registration Statement on Form S-1 filed October 26,
2020

       Exhibit 5.2, page 1

   1.                                                   Please revise to remove
the "solely" language in the last paragraph. Purchasers of the
                                                        securities in the
offering are entitled to rely on the opinion expressed. For guidance you
                                                        may wish to refer to
Section II.B.3.a. of Staff Legal Bulletin No. 19 (CF).
 Gad Soffer
FirstName  LastNameGad SofferCorp.
Consonance-HFW   Acquisition
Comapany
October 26,NameConsonance-HFW
            2020                 Acquisition Corp.
October
Page 2 26, 2020 Page 2
FirstName LastName
       Please contact Edward M. Kelly, Senior Counsel, at (202) 551-3728 or
Erin M. Purnell,
Senior Counsel, at (202) 551-3454 with any questions.



                                                          Sincerely,

                                                          Division of
Corporation Finance
                                                          Office of
Manufacturing