<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0206</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2020-10-26</periodOfReport>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001823767</issuerCik>
        <issuerName>Lux Health Tech Acquisition Corp.</issuerName>
        <issuerTradingSymbol>LUXA</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001829620</rptOwnerCik>
            <rptOwnerName>Lux Encore Sponsor, LP</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O LUX HEALTH TECH ACQUISITION CORP.</rptOwnerStreet1>
            <rptOwnerStreet2>920 BROADWAY, 11TH FLOOR</rptOwnerStreet2>
            <rptOwnerCity>NEW YORK</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10010</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001829994</rptOwnerCik>
            <rptOwnerName>Lux Encore Holdings, LLC</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O LUX HEALTH ACQUISITION CORP.</rptOwnerStreet1>
            <rptOwnerStreet2>920 BROADWAY, 11TH FLOOR</rptOwnerStreet2>
            <rptOwnerCity>NEW YORK</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10010</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001830001</rptOwnerCik>
            <rptOwnerName>Wolfe Josh</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O LUX HEALTH ACQUISITION CORP.</rptOwnerStreet1>
            <rptOwnerStreet2>920 BROADWAY, 11TH FLOOR</rptOwnerStreet2>
            <rptOwnerCity>NEW YORK</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10010</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001683771</rptOwnerCik>
            <rptOwnerName>Hebert Peter</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O LUX HEALTH ACQUISITION CORP.</rptOwnerStreet1>
            <rptOwnerStreet2>920 BROADWAY, 11TH FLOOR</rptOwnerStreet2>
            <rptOwnerCity>NEW YORK</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10010</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <derivativeTable>
        <derivativeHolding>
            <securityTitle>
                <value>Class B Common Stock</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <footnoteId id="F1"/>
            </conversionOrExercisePrice>
            <exerciseDate>
                <footnoteId id="F1"/>
            </exerciseDate>
            <expirationDate>
                <footnoteId id="F1"/>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Class A Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>8505000</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See footnote</value>
                    <footnoteId id="F2"/>
                </natureOfOwnership>
            </ownershipNature>
        </derivativeHolding>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">The Class B common stock will automatically convert into shares of Class A common stock at the completion of the Issuer's initial business combination on a one-for-one basis, subject to adjustment.</footnote>
        <footnote id="F2">Lux Encore Sponsor, LP (&quot;Sponsor&quot;) is the record holder of the shares reported herein. Lux Encore Holdings, LLC (&quot;Lux GP&quot;) is the general partner of Sponsor. Josh Wolfe and Peter Hebert are the managing members of Lux GP. As such, Lux GP and each of Messers. Wolfe and Hebert may be deemed to share beneficial ownership of the Class B common stock held directly by Sponsor. Lux GP and Messers. Wolfe and Hebert disclaim any beneficial ownership of such shares other than to the extent of their pecuniary interest therein.</footnote>
    </footnotes>

    <remarks>Exhibit List
Exhibit 24.1 - Power of Attorney
Exhibit 24.2 - Power of Attorney</remarks>

    <ownerSignature>
        <signatureName>Lux Encore Sponsor, LP, By: Lux Encore Holdings, LLC, its general partner, By: /s/ Segolene Scarborough, Attorney-in-Fact for Peter Hebert, Managing Member, By: /s/ Segolene Scarborough, Attorney-in-Fact for Josh Wolfe, Managing Member</signatureName>
        <signatureDate>2020-10-26</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>Lux Encore Holdings, LLC, By: /s/ Segolene Scarborough, Attorney-in-Fact for Peter Hebert, Managing Member, By: /s/ Segolene Scarborough, Attorney-in-Fact for Josh Wolfe, Managing Member</signatureName>
        <signatureDate>2020-10-26</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Segolene Scarborough, Attorney-in-Fact for Josh Wolfe</signatureName>
        <signatureDate>2020-10-26</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Segolene Scarborough, Attorney-in-Fact for Peter Hebert</signatureName>
        <signatureDate>2020-10-26</signatureDate>
    </ownerSignature>
</ownershipDocument>
