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Stock-Based Compensation (Tables)
 9 Months Ended
Sep. 30, 2022
Share-Based Payment Arrangement [Abstract]  
Summary of Stock Option Activities
A summary of the stock option activity, including the CEO Performance Award, for the nine months ended September 30, 2022 is as follows (in thousands, except share amounts, per share amounts, and years):
 
Options
Outstanding
Weighted-
Average
Exercise
Price
Weighted-
Average
Remaining
Life (Years)
Aggregate
Intrinsic
Value
Outstanding at December 31, 2021
7,684,778$12.91 9.04$188,722 
Exercised(921,742)$1.88 
Cancelled/Forfeited(1,974,012)$17.68 
Outstanding at September 30, 2022
4,789,024$13.25 5.27$12,004 
 Vested and exercisable at September 30, 2022
2,398,336$8.79 5.32$7,612 
Summary of Nonvested Restricted Stock Unit Awards
The following table summarizes the activity related to RSUs for the nine months ended September 30, 2022:
 
RSUs
Outstanding
Weighted-Average
Grant Date Fair
Value per Share
Unvested and outstanding at December 31, 2021
5,949,798 $46.54 
Granted10,355,782 $8.79 
Vested(2,019,222)$39.01 
Cancelled(2,086,309)$35.33 
Unvested and outstanding at September 30, 2022
12,200,049 $17.66 
Vested and outstanding at September 30, 2022
115,150 $28.28 
Summary of Nonvested Shareholder Value Awards Activity
The following table summarizes the activity related to SVAs for the nine months ended September 30, 2022:
 
SVAs
Outstanding
Weighted-Average
Grant Date Fair
Value per Share
Unvested and outstanding at December 31, 2021
315,559 $5.29 
Vested(172,504)$4.79 
Cancelled(51,781)$2.97 
Unvested and outstanding at September 30, 2022
91,274 $7.55 
Vested and outstanding at September 30, 2022
— $— 
Summary of Total Stock-based Compensation Expense
Total stock-based compensation expense was as follows (in thousands):
Three Months Ended September 30,Nine Months Ended September 30,
2021202220212022
Research and development$22,382 $16,915 $49,520 $56,771 
Selling, general and administrative9,700 6,117 41,360 18,939 
Total stock-based compensation expense$32,082 $23,032 $90,880 $75,710