Income Taxes - Narrative (Details) - USD ($)	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019	Dec. 31, 2018
Income Tax Disclosure [Abstract]
Effective tax rate	0.00%	0.00%	0.00%
Total unrecognized tax benefits	$ 6,900,000	$ 4,766,000	$ 4,029,000	$ 2,850,000
Unrecognized tax benefits that would impact effective tax rate	5,800,000
Accrued interest or penalties related to unrecognized tax benefits	0	0	0
Net operating loss carryforwards	971,500,000
Net operating loss carryforwards deferred tax assets	155,088,000	74,417,000	39,489,000
Net operating loss carryforwards, expiration	445,900,000
Net operating loss carryforwards, no expiration	525,600,000
Net operating loss carryforwards, not sustained upon examination	40,300,000
Research and development tax credit carryforward	23,700,000
Tax credit carryforwards subject to expiration	16,200,000
Tax credit carryforwards not subject to expiration	7,500,000
Net change in total valuation allowance	$ 100,000,000	$ 40,900,000	$ 25,800,000