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Stock-Based Compensation - Schedule of Estimated Grant Date Fair Value of ESPP (Details) - $ / shares
12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]      
Expected dividend yield 0.00%    
Employee Stock      
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]      
Risk-free interest rate 0.06%    
Expected dividend yield 0.00%    
Expected volatility 97.10%    
Expected term (in years) 6 months    
Fair value of ordinary shares (in dollars per share) $ 44.39    
Stock Options      
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]      
Risk-free interest rate     0.00%
Expected dividend yield 0.00% 0.00% 0.00%
Expected volatility 50.00%   0.00%
Fair value of ordinary shares (in dollars per share)     $ 0
Risk-free interest rate maximum 1.25% 0.44%  
Risk-free interest rate minimum 0.33% 0.14%