X0306 4 2022-03-07 0 0001823593 TuSimple Holdings Inc. TSP 0001336664 Buss Brad W 9191 TOWNE CENTRE DRIVE, STE 600 SAN DIEGO CA 92122 1 0 0 0 Class A Common Stock 2022-03-07 4 P 0 25000 11.1707 A 42680 D Class A Common Stock 141441 I By trust Class A Common Stock 141442 I By trust The price reported in Column 4 is a weighted average price. These shares were acquired in multiple transactions at prices ranging from $11.01 to $11.52, inclusive. The reporting person undertakes to provide to the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares acquired at each separate price within the ranges set forth in this footnote 1 to this Form 4. The shares are held by the 2011 Buss Family Trust, of which the Reporting Person is trustee. The shares are held by the Buss Family Heritage Trust, of which the Reporting Person is trustee. /s/ Laura Donald - Attorney-in-Fact 2022-03-07