X0306 4 2021-04-01 0001484612 Outset Medical, Inc. OM 0001823380 Vazquez Martin 3052 ORCHARD DRIVE SAN JOSE CA 95134 true Chief Operating Officer Common Stock 2021-04-01 4 M 0 12716 3.88 A 21971 D Common Stock 2021-04-01 4 M 0 9784 3.88 A 31755 D Common Stock 2021-04-01 4 S 0 19997 55.013 D 11758 D Common Stock 2021-04-01 4 S 0 2503 55.3625 D 9255 D Performance Stock Option (Right to Buy) 3.88 2021-04-01 4 M 0 12716 0 D 2018-09-30 2027-12-19 Common Stock 12716 0 D Performance Stock Option (Right to Buy) 3.88 2021-04-01 4 M 0 9784 0 D 2018-12-21 2027-12-19 Common Stock 9784 2932 D The price reported in Column 4 is a weighted average price. The shares of common stock of the Issuer were sold in multiple transactions at prices ranging from $54.23 to $55.222, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote (1). The price reported in Column 4 is a weighted average price. The shares of common stock of the Issuer were sold in multiple transactions at prices ranging from $55.23 to $55.58, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote (2). The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 14, 2020. This Form 4 corrects the exercise price previously reported as $3.87 on the Form 3 filed on September 14, 2020. /s/ John L. Brottem, attorney-in-fact for Martin Vazquez 2021-04-05