X0306 4 2022-03-23 false 0001822791 Clene Inc. CLNN 0001251956 MATLIN DAVID J 61 CEDAR POINT LANE SAG HARBOR NY 11963 true false false false Common Stock 2022-03-23 4 P false 20000.00 2.94 A 1672749.00 D Common Stock 2022-03-24 4 P false 20000.00 2.99 A 1692749.00 D Common Stock 150000.00 I By trust Mr. Matlin purchased 20,000 shares of common stock of Clene Inc. in multiple transactions on March 23, 2022 at prices ranging from $2.85 to $3.01, inclusive, for a weighted average price of $2.94 per share. Mr. Matlin purchased 20,000 shares of common stock of Clene Inc. in multiple transactions on March 24, 2022 at prices ranging from $2.91 to $3.05, inclusive, for a weighted average price of $2.99 per share. The securities are owned by the Matlin Family Trust 2020. Mr. Matlin is the trustee of the Matlin Family Trust 2020. The shares owned by the Matlin Family Trust 2020 may be deemed to be beneficially owned by Mr. Matlin. /s/ Jerry Miraglia POA 2022-03-25