X0202 SCHEDULE 13G/A 0001104659-22-022224 0001835537 XXXXXXXX LIVE 4 Common Stock, $0.0001 par value 03/31/2026 0001822791 Clene Inc. 185634201 6550 South Millrock Drive Suite G50 Salt Lake City UT 84121 Rule 13d-1(d) Alison Mosca X1 59928.00 1772062.00 59928.00 1772062.00 1831990.00 N 13.0 IN Sole Voting and Dispositive Power includes options to purchase 57,955 shares of common stock; Shared Voting and Dispositive Power includes warrants to purchase 350,801 shares of common stock and 917,431 shares subject to conversion from a promissory note. The convertible note includes a provision limiting the Reporting Person's ability to convert certain amounts into common shares to the extent such conversion, together with the exercise of any warrants held by the Reporting Person, would require stockholder approval under the rules or regulations of the Nasdaq Stock Market. Clene Inc. 6550 South Millrock Drive, Suite G50, Salt Lake City, UT 84121 Alison Mosca c/o Kensington Capital Holdings, LLC, 26 Patriot Place, Suite 301, Foxboro, MA 02035 United States of America Y 1,831,990 (Includes the following: 1,973 shares of Common Stock held directly, 280,500 shares of Common Stock held by Kensington Clene 2021, LLC, for which Ms. Mosca is the sole manager of and owns a minority interest, 72,997 shares of Common Stock held by the Robert C. Gay 1998 Family Trust (the "Family Trust"), for which Ms. Mosca serves as trustee, and 150,333 shares of Common Stock held by Kensington Investments, L.P., for which Ms. Mosca serves as the chief executive officer. By reason of the provisions of Rule 13d-3 of the Act, Ms. Mosca may be deemed to beneficially own the shares beneficially owned by Kensington Clene 2021, LLC, the Family Trust, and Kensington Investments, L.P. Ms. Mosca disclaims beneficial ownership of the securities held in Kensington Clene 2021, LLC, the Family Trust, Kensington Clene 2024, LLC, and Kensington Investments, L.P. except to her pecuniary interest therein and this report shall not be deemed as an admission of beneficial ownership of the reported securities. Also includes options to purchase 57,955 shares of common stock, warrants to purchase 350,801 shares of common stock, and 917,431 shares subject to conversion from a promissory note issued by Kensington Clene 2024, LLC, for which Ms. Mosca is the sole manager of and owns a minority interest. The convertible note includes a provision limiting the Reporting Person's ability to convert certain amounts into common shares to the extent such conversion, together with the exercise of any warrants held by the Reporting Person, would require stockholder approval under the rules or regulations of the Nasdaq Stock Market. Kensington Clene 2021, LLC had been incorrectly referred to in the original Schedule 13G for Ms. Mosca as Kensington Clene, LLC; there is no such legal entity. 13.0% (based on 12,778,307 shares of Common Stock outstanding as represented in the Issuer's Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission on May 14, 2026.) 59,928 (Includes 1,973 shares held directly and options to purchase 57,955 shares of common stock.) 1,772,062 (Includes 280,500 shares of Common Stock held by Kensington Clene, LLC 2021, 72,997 shares of Common Stock held by the Family Trust, 150,333 shares of Common Stock held by Kensington Investments, L.P., warrants to purchase 350,801 shares of Common Stock, and 917,431 shares subject to conversion from a promissory note.) 59,928 (Includes 1,973 shares held directly and options to purchase 57,955 shares of common stock.) 1,772,062 (Includes 280,500 shares of Common Stock held by Kensington Clene, LLC 2021, 72,997 shares of Common Stock held by the Family Trust, 150,333 shares of Common Stock held by Kensington Investments, L.P., warrants to purchase 350,801 shares of Common Stock, and 917,431 shares subject to conversion from a promissory note.) Y Y Y Y Y Y Alison Mosca /s/ Alison Mosca 05/14/2026