Consolidated Statements of Cash Flows - USD ($)	12 Months Ended
	Dec. 31, 2024	Dec. 31, 2023
Cash flows from operating activities:
Net loss	$ (86,620,000)	$ (98,426,000)
Adjustments to reconcile net loss to net cash provided by (used in) operating activities:
Stock-based compensation expense	11,893,000	16,186,000
Depreciation and amortization expense	3,120,000	3,451,000
Loss on disposal of property and equipment	0	3,000
Impairment of long-lived assets	2,398,000	0
Noncash lease expense	5,682,000	5,210,000
Accretion of discount on marketable securities	(4,613,000)	(2,651,000)
Changes in operating assets and liabilities:
Prepaid expenses and other current assets	1,317,000	741,000
Accounts payable	(2,475,000)	846,000
Accrued expenses and other liabilities	(564,000)	(1,797,000)
Operating lease liabilities	(7,942,000)	(7,514,000)
Deferred revenue	(22,602,000)	(34,155,000)
Net cash used in operating activities	(100,406,000)	(118,106,000)
Cash flows from investing activities:
Purchases of property and equipment	(906,000)	(1,224,000)
Purchases of marketable securities	(261,470,000)	(73,901,000)
Proceeds from maturities of marketable securities	232,472,000	219,575,000
Net cash provided by (used in) investing activities	(29,904,000)	144,450,000
Cash flows from financing activities:
Proceeds from offerings of common stock and pre-funded warrants, net of underwriting discounts and commissions	103,401,000	0
Payments of public offering costs	(585,000)	0
Proceeds from issuance of common stock upon exercise of stock options	2,612,000	1,778,000
Net cash provided by financing activities	105,428,000	1,778,000
Net increase (decrease) in cash, cash equivalents and restricted cash	(24,882,000)	28,122,000
Cash, cash equivalents and restricted cash at beginning of period	82,044,000	53,922,000
Cash, cash equivalents and restricted cash at end of period	57,162,000	82,044,000
Supplemental cash flow information:
Cash paid for taxes	860,000	3,551,000
Supplemental disclosure of noncash investing and financing information:
Purchases of property and equipment included in accounts payable and accrued expenses	22,000	35,000
Reconciliation of cash, cash equivalents and restricted cash:
Cash and cash equivalents	55,454,000	80,336,000
Restricted cash (non-current)	1,708,000	1,708,000
Total cash, cash equivalents and restricted cash shown in the statement of cash flows	$ 57,162,000	$ 82,044,000