<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0206</schemaVersion>

    <documentType>3/A</documentType>

    <periodOfReport>2022-08-16</periodOfReport>

    <dateOfOriginalSubmission>2022-08-18</dateOfOriginalSubmission>

    <noSecuritiesOwned>1</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001822462</issuerCik>
        <issuerName>Foghorn Therapeutics Inc.</issuerName>
        <issuerTradingSymbol>FHTX</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001073385</rptOwnerCik>
            <rptOwnerName>PARSHALL B LYNNE</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>500 TECHNOLOGY SQUARE</rptOwnerStreet1>
            <rptOwnerStreet2>STE 700</rptOwnerStreet2>
            <rptOwnerCity>CAMBRIDGE</rptOwnerCity>
            <rptOwnerState>MA</rptOwnerState>
            <rptOwnerZipCode>02139</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>true</isDirector>
            <isOfficer>false</isOfficer>
            <isTenPercentOwner>false</isTenPercentOwner>
            <isOther>false</isOther>
            <officerTitle></officerTitle>
            <otherText></otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable></nonDerivativeTable>

    <derivativeTable></derivativeTable>

    <footnotes></footnotes>

    <remarks>This Form 3/A is being filed solely to include the Reporting Person's Power of Attorney as Exhibit 24.</remarks>

    <ownerSignature>
        <signatureName>/s /Allan Reine, M.D., Attorney-in-Fact</signatureName>
        <signatureDate>2022-09-09</signatureDate>
    </ownerSignature>
</ownershipDocument>
