<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001055947</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001821586</issuerCik>
      <issuerName>MoonLake Immunotherapeutics</issuerName>
      <secFileNumber>001-39630</secFileNumber>
      <issuerAddress>
        <com:street1>DORFSTRASSE 29</com:street1>
        <com:city>ZUG</com:city>
        <com:stateOrCountry>V8</com:stateOrCountry>
        <com:zipCode>6300</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>41 41 510 8022</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>BVF PARTNERS L P/IL</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>10% Stockholder</relationshipToIssuer>
        <relationshipToIssuer>Affiliate of Director</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Goldman Sachs &amp; Co. LLC</name>
        <address>
          <com:street1>200 West Street</com:street1>
          <com:city>New York</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>10282</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>3750000</noOfUnitsSold>
      <aggregateMarketValue>63487500.00</aggregateMarketValue>
      <noOfUnitsOutstanding>71727875</noOfUnitsOutstanding>
      <approxSaleDate>03/31/2026</approxSaleDate>
      <securitiesExchangeName>NASDAQ</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <acquiredDate>04/05/2022</acquiredDate>
      <natureOfAcquisitionTransaction>Acquired upon the automatic conversion of private shares in connection with the consummation of the Issuer's business combination on April 5, 2022. The private shares were acquired and fully paid for on May 4, 2021.</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>18501284</amountOfSecuritiesAcquired>
      <paymentDate>04/05/2022</paymentDate>
      <natureOfPayment>Merger consideration relating to the Issuer's business combination which occurred on April 5, 2022</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <remarks>BVF Partners, L.P. (BVF) is the investment manager of certain funds and/or managed accounts that are selling the shares. BVF is also an affiliate of a director of the Issuer. The aggregate market value is as of the close of business on March 30, 2026. The number of securities outstanding is as of February 1, 2026.</remarks>
    <noticeSignature>
      <noticeDate>03/31/2026</noticeDate>
      <signature>Mark N. Lampert, President of BVF Inc., the general partner of BVF</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
