X0306 4 2022-01-10 0 0001815442 Kymera Therapeutics, Inc. KYMR 0001821189 Mainolfi Nello C/O KYMERA THERAPEUTICS, INC. 200 ARSENAL YARDS BLVD., SUITE 230 WATERTOWN MA 02472 1 1 0 0 Chief Executive Officer Common Stock 2022-01-10 4 M 0 22465 2.08 A 494664 D Common Stock 2022-01-10 4 S 0 7485 52.4574 D 487179 D Common Stock 2022-01-10 4 S 0 10673 53.3476 D 476506 D Common Stock 2022-01-10 4 S 0 4201 54.4026 D 472305 D Common Stock 2022-01-10 4 S 0 106 54.99 D 472199 D Common Stock 2022-01-11 4 M 0 16923 2.08 A 489122 D Common Stock 2022-01-11 4 S 0 9932 53.6759 D 479190 D Common Stock 2022-01-11 4 S 0 6644 54.4224 D 472546 D Common Stock 2022-01-11 4 S 0 347 55.0529 D 472199 D Common Stock 2022-01-12 4 M 0 8612 2.08 A 480811 D Common Stock 2022-01-12 4 S 0 2726 51.3122 D 478085 D Common Stock 2022-01-12 4 S 0 4022 52.0163 D 474063 D Common Stock 2022-01-12 4 S 0 1623 53.27 D 472440 D Common Stock 2022-01-12 4 S 0 241 53.97 D 472199 D Stock Option (Right to Buy) 2.08 2022-01-10 4 M 0 22465 0.00 D 2029-11-13 Common Stock 22465 599815 D Stock Option (Right to Buy) 2.08 2022-01-11 4 M 0 16923 0.00 D 2029-11-13 Common Stock 16923 582892 D Stock Option (Right to Buy) 2.08 2022-01-12 4 M 0 8612 0.00 D 2029-11-13 Common Stock 8612 574280 D This sale was effected pursuant to a Rule 10b5-1 trading plan adopted on November 6, 2020. The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $51.99 to $52.96. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request. The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $52.99 to $53.98. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request. The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $53.99 to $54.66. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request. The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $53.01 to $54.00. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request. The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $54.01 to $54.995. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request. The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $55.05 to $55.06. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request. The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $50.60 to $51.575. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request. The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $51.60 to $52.59. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request. The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $52.88 to $53.59. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request. The shares underlying this stock option vest in forty-eight (48) equal monthly installments following the vesting commencement date of November 14, 2019, subject to the reporting person's continued employment through each vesting date. /s/ Bruce Jacobs, as Attorney-in-Fact 2022-01-12