X0306 4 2021-10-08 0 0001815442 Kymera Therapeutics, Inc. KYMR 0001821189 Mainolfi Nello C/O KYMERA THERAPEUTICS, INC. 200 ARSENAL YARDS BLVD., SUITE 230 WATERTOWN MA 02472 1 1 0 0 Chief Executive Officer Common Stock 2021-10-08 4 M 0 41544 2.08 A 505743 D Common Stock 2021-10-08 4 S 0 21236 55.5598 D 484507 D Common Stock 2021-10-08 4 S 0 9369 56.8247 D 475138 D Common Stock 2021-10-08 4 S 0 2078 57.2887 D 473060 D Common Stock 2021-10-08 4 S 0 7920 59.2756 D 465140 D Common Stock 2021-10-08 4 S 0 670 60.3165 D 464470 D Common Stock 2021-10-08 4 S 0 271 61.87 D 464199 D Common Stock 2021-10-11 4 M 0 6456 2.08 A 470655 D Common Stock 2021-10-11 4 S 0 5712 53.5791 D 464943 D Common Stock 2021-10-11 4 S 0 744 54.4979 D 464199 D Stock Option (Right to Buy) 2.08 2021-10-08 4 M 0 41544 0.00 D 2029-11-13 Common Stock 41544 35181 D Stock Option (Right to Buy) 2.08 2021-10-11 4 M 0 6456 0.00 D 2029-11-13 Common Stock 6456 28725 D This sale was effected pursuant to a Rule 10b5-1 trading plan adopted on November 6, 2020. The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $55.10 to $56.09. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request. The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $56.19 to $57.185. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request. The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $57.20 to $58.14. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request. The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $58.90 to $59.81. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request. The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $59.91 to $60.61. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request. The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $53.19 to $54.16. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request. The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $54.28 to $54.60. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request. The shares underlying this stock option shall vest upon the achievement of specified performance-based milestones. /s/ Bruce Jacobs, as Attorney-in-Fact 2021-10-12