X0206 3 2020-08-18 0 0001802665 Harmony Biosciences Holdings, Inc. HRMY 0001820836 Jacobs John C 630 W. GERMANTOWN PIKE, SUITE 215 PLYMOUTH MEETING PA 19462 1 1 0 0 President, CEO Stock Option 8.22 2027-10-02 Common Stock 314751 D Stock Option 8.22 2028-10-01 Common Stock 121728 D Stock Option 8.22 2030-03-04 Common Stock 38160 D The stock option is currently vested with respect to 188,851 shares, and will vest with respect to the remainder of the shares in three equal annual installments beginning on October 2, 2020. The stock option is currently vested with respect to 48,691 shares, and will vest with respect to the remander of the shares in four equal annual installments beginning on October 1, 2020. The stock option will vest in five equal annual installments beginning on March 4, 2021. Exhibit 24 - Power of Attorney. /s/ Stephanie Wisdo, Attorney-in-fact for John C. Jacobs 2020-08-18