CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS (UNAUDITED) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
Cash flows from operating activities:
Net loss	$ (50,078)	$ (52,162)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	3,381	3,759
Stock-based compensation	4,642	2,997
Amortization of debt discount and issuance costs	3,337	3,755
Accretion of debt end of term charge and PIK interest	1,812	2,258
Loss on valuation of derivative and warrant liabilities	0	16,321
Others	494	(5)
Changes in operating assets and liabilities:
Accounts receivable	3,287	364
Inventory	(13,830)	364
Prepaid expenses and other current assets	333	(3,463)
Deferred cost of goods sold	(824)	117
Operating lease right-of-use assets and liabilities	4	(35)
Other assets	309	122
Accounts payable and accrued liabilities	(3,485)	10,071
Deferred revenue, current and non-current	(1,664)	(1,470)
Other non-current liabilities	134	1,258
Net cash used in operating activities	(52,148)	(15,749)
Cash flows from investing activities:
Purchase of investments	(202,479)	(111,504)
Proceeds from maturities of investments	140,000	49,000
Purchase of property and equipment	(9,173)	(1,251)
Net cash used in investing activities	(71,652)	(63,755)
Cash flows from financing activities:
Repayment of finance obligation	(8)	(121)
Repayment of government grants	(700)	0
Proceeds from exercise of stock options	1,833	2,024
Net cash provided by financing activities	1,125	1,903
Net decrease in cash and cash equivalents, and restricted cash	(122,675)	(77,601)
Cash and cash equivalents, and restricted cash at the beginning of period	182,604	123,697
Cash and cash equivalents, and restricted cash at the end of period	59,929	46,096
Supplemental disclosures of cash flow information:
Cash paid for interest	2,094	2,706
Cash paid for income taxes	0	0
Non-cash investing and financing activity:
Assets acquired through accounts payable and accrued liabilities	$ 7,087	$ 1,789