X0202 SCHEDULE 13G/A 0001104659-23-093931 0001916761 XXXXXXXX LIVE 1 Common Stock, $0.001 par value per share 03/31/2026 0001819133 Tango Therapeutics, Inc. 87583X109 201 Brookline Ave., Suite 901 Boston MA 02215 Rule 13d-1(c) Nextech Crossover I GP S.a. r.l. b N4 7266081.00 0.00 7266081.00 0.00 7266081.00 5.1 OO Nextech Crossover I SCSp b N4 7266081.00 0.00 7266081.00 0.00 7266081.00 5.1 PN Ian Charoub b V7 0.00 7266081.00 0.00 7266081.00 7266081.00 5.1 IN Costas Constantinides b G4 0.00 7266081.00 0.00 7266081.00 7266081.00 5.1 IN Rocco Sgobbo b V8 0.00 7266081.00 0.00 7266081.00 7266081.00 5.1 IN Tango Therapeutics, Inc. 201 Brookline Ave., Suite 901, Boston, MA, 02215. The names of the persons filing this report (collectively, the 'Reporting Persons') are: Nextech Crossover I SCSp ('Nextech Crossover LP') Nextech Crossover I GP S.a r.l. ('Nextech Crossover GP') Ian Charoub ('Charoub') Costas Constantinides ('Constantinides') Rocco Sgobbo ('Sgobbo') The Reporting Persons expressly disclaim status as a 'group' for purposes of this Schedule 13G. Bahnhofstrasse 18 Zurich, Switzerland 8001 Nextech Crossover LP Luxembourg Nextech Crossover GP Luxembourg Charoub Sweden Constantinides Cyprus Sgobbo Switzerland Y Row 9 of each Reporting Person's cover page to this Schedule 13G sets forth the aggregate number of shares of common stock of the Issuer beneficially owned by such Reporting Person as of March 31, 2026 and is incorporated by reference. Nextech Crossover LP directly holds 7,266,081 shares of common stock. Nextech Crossover GP serves as the sole general partner of Nextech Crossover LP and Charoub, Constantinides and Sgobbo are members of the board of managers of Nextech Crossover GP. Each of Nextech Crossover GP, Charoub, Constantinides and Sgobbo possesses power to direct the voting and disposition of the securities held by Nextech Crossover LP. Row 11 of each Reporting Person's cover page to this Schedule 13G sets forth the percentages of the shares of common stock of the Issuer beneficially owned by such Reporting Person as of March 31, 2026 and is incorporated by reference. The percentage set forth in each row 11 is based upon 142,688,851 shares of common stock outstanding as of February 26, 2026, as reported in the Issuer's Annual Report on Form 10-K filed with the Securities and Exchange Commission (the "SEC") on March 5, 2026. Row 5 of each Reporting Person's cover page to this Schedule 13G sets forth the sole power to vote or to direct the vote of securities of the Issuer beneficially owned by such Reporting Person as of March 31, 2026 and is incorporated by reference. Row 6 of each Reporting Person's cover page to this Schedule 13G sets forth the shared power to vote or to direct the vote of securities of the Issuer beneficially owned by such Reporting Person as of March 31, 2026 and is incorporated by reference. Row 7 of each Reporting Person's cover page to this Schedule 13G sets forth the sole power to dispose or to direct the disposition of securities of the Issuer beneficially owned by such Reporting Person as of March 31, 2026 and is incorporated by reference. Row 8 of each Reporting Person's cover page to this Schedule 13G sets forth the shared power to dispose or to direct the disposition of securities of the Issuer beneficially owned by such Reporting Person as of March 31, 2026 and is incorporated by reference. Y Y Y Y Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11. Exhibit 99.1 Joint Filing Agreement (incorporated by reference to Exhibit A to the Schedule 13G filed by the Reporting Persons with the SEC on August 21, 2023). Nextech Crossover I GP S.a. r.l. /s/ Ian Charoub 05/15/2026 /s/ Costas Constantinides 05/15/2026 Nextech Crossover I SCSp /s/ Ian Charoub 05/15/2026 /s/ Costas Constantinides 05/15/2026 Ian Charoub /s/ Ian Charoub 05/15/2026 Costas Constantinides /s/ Costas Constantinides 05/15/2026 Rocco Sgobbo /s/ Rocco Sgobbo 05/15/2026