144 0001688327 XXXXXXXX LIVE 0001819133 TANGO THERAPEUTICS, INC. 001-39485 201 Brookline Ave., Suite 901 Boston MA 02215 (857) 320-4900 Third Rock Ventures IV, L.P. 10% Stockholder Common BTIG, LLC

350 Bush Street 9th Floor San Francisco CA 94104

642906 4461767.00 111260247 09/05/2025 NASDAQ GM common 03/23/2017 Pre-IPO investment Tango Therapeutics Inc N 642906 03/23/2017 Wire N Third Rock Ventures IV, L.P.

201 BROOKLINE AVENUE Suite 1401 BOSTON MA 02215

common 08/19/2025 1100000 7712760.00 Third Rock Ventures IV, L.P.

201 BROOKLINE AVENUE Suite 1401 BOSTON MA 02215

common 08/22/2025 302194 2115358.00 09/05/2025 Kevin Gillis