144 0001688327 XXXXXXXX LIVE 0001819133 Tango Therapeutics, Inc. 001-39485 201 BROOKLINE AVENUE SUITE 901 BOSTON MA 02215 (857) 320-4900 Third Rock Ventures IV, L.P. 10% Stockholder Common BTIG, LLC

350 Bush Street 9th Floor San Francisco CA 94104

302194 2085138.60 111260247 08/22/2025 NASDAQ GM Common 03/23/2017 Pre-IPO investment Tango Therapeutics Inc N 302194 03/23/2017 Wire N Third Rock Ventures IV, L.P.

201 BROOKLINE AVENUE Suite 1401 BOSTON MA 02215

Common 08/19/2025 1100000 7712760.00 08/22/2025 Kevin Gillis