144 0001688327 XXXXXXXX LIVE 0001819133 Tango Therapeutics, Inc. 001-39485 201 BROOKLINE AVENUE SUITE 901 BOSTON MA 02215 (857) 320-4900 Third Rock Ventures IV, L.P. Affiliate Common BTIG, LLC

350 Bush St. 9th floor San Francisco CA 94104

100599 990900.15 106846262 07/25/2024 NASD Common 02/08/2017 Pre-IPO Purchased from TRV III and Issuer N 36733 02/08/2017 Wire Common 02/08/2017 Pre-IPO Purchased from TRV III N 3397 02/08/2017 Wire Common 03/17/2017 Pre-IPO Purchased from TRV III N 60469 03/17/2017 Wire N Third Rock Ventures IV, L.P.

201 Brookline Ave Suite 1401 Boston MA 02215

Common 07/17/2024 550171 5386339.14 Third Rock Ventures IV, L.P.

201 Brookline Ave Suite 1401 Boston MA 02215

Common 07/18/2024 191490 1878478.60 Third Rock Ventures IV, L.P.

201 Brookline Ave Suite 1401 Boston MA 02215

Common 07/22/2024 262740 2570096.41 Third Rock Ventures IV, L.P.

201 Brookline Ave Suite 1401 Boston MA 02215

Common 07/23/2024 125000 1223350.00 Third Rock Ventures IV, L.P.

201 Brookline Ave Suite 1401 Boston MA 02215

Common 07/24/2024 200000 1963160.00 07/25/2024 Kevin Gillis