Income Taxes (Tables)

12 Months Ended

Dec. 31, 2021

Income Tax Disclosure [Abstract]

Schedule of Reconciliation of U.S. Federal Statutory Income Tax Rate to Company's Effective Income Tax Rate

A reconciliation of the U.S. federal statutory income tax rate to the Company’s effective income tax rate is as follows:

	Year Ended December 31,
	2021			2020
Income taxes at U.S. federal statutory rate		21.0	%		21.0	%
State income taxes, net of federal benefit	6.1				5.9
Federal and state research and development tax credits	5.4				4.4
Stock-based compensation expense		(1.1	)		(0.7	)
Nondeductible/nontaxable permanent items		0.6			—
Other		(0.3	)		(1.7	)
Change in valuation allowance		(32.1	)		(28.9	)
Effective tax rate		(0.4	)%	—%

Schedule of Deferred Tax Assets and Liabilities

The tax effects of temporary differences that give rise to significant components of the deferred tax assets and liabilities are as follows:

	Year Ended December 31,
	2021			2020
	(in thousands)
Deferred tax assets
Net operating loss carryforwards	$	4,403		$	11,085
Research and development credit carryforwards		7,084			5,213
Operating lease liability		411			2,154
Deferred revenue		34,625			11,891
Accruals and reserves		958			648
Capitalized research costs		2,193			2,506
Other		1,008			88
Total gross deferred tax assets		50,682			33,585
Valuation allowance		(49,568	)		(30,945	)
Net deferred tax assets	$	1,114		$	2,640
Deferred tax liabilities
Depreciation	$	(771	)	$	(597	)
Right-of-use asset		(343	)		(2,043	)
Total gross deferred tax liabilities		(1,114	)		(2,640	)
Net deferred taxes	$	—		$	—