X0407 4 2023-06-06 0 0001819133 Tango Therapeutics, Inc. TNGX 0001876563 Peters Malte C/O TANGO THERAPEUTICS, INC 201 BROOKLINE AVE., SUITE 901 BOSTON MA 02215 1 0 0 0 0 Common Stock 2023-06-06 4 A 0 5000 0.00 A 5000 D Stock Option (Right to Buy) 3.55 2023-06-06 4 A 0 30000 0.00 A 2033-06-06 Common Stock 30000 30000 D These shares are represented by restricted stock units (the "RSUs"). Each RSU represents a contingent right to receive one share of Common Stock of the Issuer. The RSUs will vest in its entirety on the earlier of: (i) June 6, 2024 and (ii) the date of the next annual meeting of stockholders, subject to the Reporting Person's continuous service with the Issuer as of each such vesting date. This option shall vest and become exercisable in 12 substantially equal monthly installments over a period of one year beginning on July 6, 2023, subject to the Reporting Person's continuous service with the Issuer as of each such vesting date. /s/ Douglas Barry, as attorney-in-fact 2023-06-08