X0407 4 2023-06-06 0 0001819133 Tango Therapeutics, Inc. TNGX 0001465914 Davis Aaron I. C/O TANGO THERAPEUTICS, INC. 201 BROOKLINE AVE., SUITE 901 BOSTON MA 02215 1 0 0 0 0 Common Stock 2023-06-06 4 A 0 5000 0.00 A 5000 D Common Stock 7123642 I See footnote Common Stock 268524 I See footnote Common Stock 6988450 I See footnote Stock Option (Right to Buy) 3.55 2023-06-06 4 A 0 30000 0.00 A 2023-06-06 Common Stock 30000 30000 D These shares are represented by restricted stock units (the "RSUs"). Each RSU represents a contingent right to receive one share of Common Stock of the Issuer. The RSUs will vest in its entirety on the earlier of: (i) June 6, 2024 and (ii) the date of the next annual meeting of stockholders, subject to the Reporting Person's continuous service with the Issuer as of each such vesting date. These securities are owned directly by Boxer Capital, LLC ("Boxer Capital"), which may be deemed to be a member of a "group" for purposes of Section 13(d) of the Securities Exchange Act of 1934, as amended, consisting of (i) Boxer Capital (ii) Boxer Asset Management Inc. , (iii) Joseph C. Lewis, (iv) BCTG Holdings, LLC, (v) MVA Investors, LLC ("MVA Investors"), and (vi) Aaron I. Davis (collectively, the "Boxer Group"). The Reporting Person disclaims beneficial ownership of these securities to the extent he does not have a pecuniary interest therein. These securities are owned directly by MVA Investors, which may be deemed to be a member of the Boxer Group. The Reporting Person disclaims beneficial ownership of these securities to the extent he does not have a pecuniary interest therein. These securities are owned directly by BCTG Holdings, LLC, which may be deemed to be a member of the Boxer Group. The Reporting Person disclaims beneficial ownership of these securities to the extent he does not have a pecuniary interest therein. This option shall vest and become exercisable in 12 substantially equal monthly installments over a period of one year beginning on July 6, 2023, subject to the Reporting Person's continuous service with the Issuer as of each such vesting date. /s/ Douglas Barry, as attorney-in-fact 2023-06-08