X0306 4 2023-03-01 0 0001819133 Tango Therapeutics, Inc. TNGX 0001513422 Beckman Daniella C/O TANGO THERAPEUTICS, INC., 201 BROOKLINE AVE., SUITE 901 BOSTON MA 02215 0 1 0 0 Chief Financial Officer Common Stock 2023-03-01 4 A 0 32842 0.00 A 96709 D Stock Option (Right to Buy) 5.20 2023-03-01 4 A 0 197051 0.00 A 2033-03-01 Common Stock 197051 197051 D These shares are represented by restricted stock units (the "RSUs"). Each RSU represents a contingent right to receive one share of Common Stock of the Issuer. The RSUs will vest over a three year period at a rate of 1/3 on February 5, 2024, 1/3 on February 3, 2025 and 1/3 on February 2, 2026 subject to the Reporting Person's continuous service with the Issuer as of each such vesting date. This option shall vest and become exercisable over a four-year period, at a rate of 25% on January 1, 2024, with the remaining option shares vesting in 36 equal monthly installments thereafter. /s/ Douglas Barry, attorney-in-fact 2023-03-02