144 0001468223 XXXXXXXX LIVE 0001819133 Tango Therapeutics, Inc. 001-39485 201 Brookline Ave Suite 901 Boston MA 02215 857-320-4900 MVA Investors, LLC member of group owning over 10% of the shares Common Stock BofA Securities Inc.

1111 Ave of the Americas One Bryant Park New York NY 10036-6706

75000 577500 106718315 05/01/2024 Nasdaq Common Stock 04/07/2020 Private Financing Tango Therapeutics, Inc. N 21082 04/07/2020 Cash Common Stock 03/11/2021 Private Financing Tango Therapeutics, Inc. N 30442 03/11/2021 Cash Common Stock 10/12/2022 Open Market Purchases Tango Therapeutics, Inc. N 23476 10/12/2022 Cash Y Aggregate Market Value as of 4/30/2024. 05/01/2024 /s/ Aaron Davis, Chief Executive Officer