X0508 4/A 2023-08-11 2023-08-15 0001819133 Tango Therapeutics, Inc. TNGX 0001465837 Boxer Capital, LLC 12860 EL CAMINO REAL SUITE 300 SAN DIEGO CA 92130 true true See remarks 0001465836 Boxer Asset Management Inc. 12860 EL CAMINO REAL SUITE 300 SAN DIEGO CA 92130 true true See remarks 0001015747 LEWIS JOSEPH C/O CAY HOUSE EP TAYLOR DRIVE N7776, LYFORD CAY NEW PROVIDENCE BAHAMAS true true See remarks 0001468223 MVA Investors, LLC 12860 EL CAMINO REAL SUITE 300 SAN DIEGO CA 92130 true true See remarks 0001465914 Davis Aaron I. 12860 EL CAMINO REAL, SUITE 300 SAN DIEGO CA 92130 true true See remarks false Common Stock 2023-08-11 4 A 0 475000 5.15 A 743542 I See footnote Common Stock 7123642 D Common Stock 5000 I See footnote Common Stock 26961 I See footnote Common Stock 6988450 I See footnote Prefunded Warrant 2023-08-11 4 A 0 2340579 5.1499 A Common Stock 2340579 2340579 D These securities are owned directly by MVA Investors, LLC ("MVA Investors"). Aaron I. Davis is a member of and has voting and dispositive power over securities held by MVA Investors. Each reporting person other than MVA Investors disclaims beneficial ownership of these securities except to the extent of such person's pecuniary interest therein, if any. These securities are owned directly by Boxer Capital, LLC ("Boxer Capital"). Boxer Asset Management Inc. is the managing member of Boxer Capital. Joseph Lewis is the sole indirect owner of Boxer Asset Management Inc. Mr. Davis is a member of Boxer Capital. Each reporting person other than Boxer Capital disclaims beneficial ownership of these securities except to the extent of such person's pecuniary interest therein, if any. These securities are owned directly by Mr. Davis. Each reporting person other than Mr. Davis disclaims beneficial ownership of these securities. These securities are owned directly by Braslyn Ltd. Mr. Lewis is the sole indirect owner of Braslyn Ltd. Each reporting person other than Mr. Lewis disclaims beneficial ownership of these securities. These securities are owned directly by BCTG Holdings, LLC ("BCTG"). Boxer Capital is the majority member of BCTG and MVA Investors is a member of BCTG. Mr. Davis is an investment manager of BCTG. Each reporting person disclaims beneficial ownership of these securities except to the extent of such person's pecuniary interest therein, if any. The prefunded warrants have an exercise price of $0.001 per share of Common Stock and are immediately exercisable and remain exercisable until exercised in full, subject to a 9.99% beneficial ownership limitation which may be increased or decreased by the holder upon 61 days' notice to the Issuer. This amended Form 4, which amends and restates in its entirety the original Form 4 filed on August 15, 2023, corrects the transaction codes in the original filing. These acquisitions were made in transactions with the Company under Rule 16b-3, as opposed to open market purchases. The reporting persons may be deemed members of a group that beneficially owns more than 10% of the outstanding shares of common stock, $0.001 par value per share, of Tango Therapeutics, Inc. (the "Issuer"). At the time of the transactions reported herein, Mr. Davis was a director of the Issuer and the other reporting persons were subject to Section 16 as directors of the Issuer on the basis of their relationships to Mr. Davis. /s/ Aaron I. Davis, Chief Executive Officer, Boxer Capital, LLC 2023-10-11 /s/ Aaron I. Davis, Chief Executive Officer, MVA Investors, LLC 2023-10-11 /s/ Paul Higgs, Director, Boxer Asset Management Inc. 2023-10-11 /s/ Joseph C. Lewis 2023-10-11 /s/ Aaron I. Davis 2023-10-11