X0306 4 2021-04-23 0 0001757898 STERIS plc STE 0001819129 Madsen Julia C/O 70 SIR ROGER'S QUAY DUBLIN L2 2 IRELAND 0 1 0 0 Senior VP, Life Sciences Ordinary Shares 2021-04-23 4 M 0 1000 69.72 A 5641 D Ordinary Shares 2021-04-23 4 S 0 1000 215.00 D 4641 D Employee Stock Option (right to buy) 69.72 2021-04-23 4 M 0 1000 0.00 A 2026-06-01 Ordinary Shares 1000 400 D 2,714 of these ordinary shares are restricted. The restrictions on these ordinary shares lapse as follows: 308 on June 1, 2021; 121 on June 1, 2021; 92 on June 1, 2021; 123 on June 1, 2021; 349 on October 1, 2021; 121 on May 31, 2022; 92 on May 31, 2022; 123 on June 1, 2022; 349 on October 3, 2022; 92 on May 31, 2023; 349 on October 2, 2023; 123 on June 1, 2023; 123 on June 3, 2024; and 349 on October 1, 2024. This exercise of stock options and sale of a total of 1,000 ordinary shares is pursuant to a Rule 10b5-1 Stock Trading Plan entered into by the Reporting Person on December 3, 2020. This option to purchase 1,000 STERIS ordinary shares, which is fully vested, was received in conjunction with the Redomiciliation of the entity organized under the laws of the U.K. and formerly named STERIS plc ("Old STERIS") in exchange for an option to purchase 1,000 Old STERIS ordinary shares for $69.72 per share, subject to the same terms and conditions as the original Old STERIS stock option, except as otherwise required by law. /s/ Ronald E. Snyder, Authorized Representative under Power of Attorney 2021-04-26