X0306 4 2020-11-09 0 0001757898 STERIS plc STE 0001819129 Madsen Julia C/O 70 SIR ROGER'S QUAY DUBLIN L2 2 IRELAND 0 1 0 0 Senior VP, Life Sciences Ordinary Shares 2020-11-09 4 M 0 1100 45.34 A 5741 D Ordinary Shares 2020-11-09 4 M 0 800 53.52 A 6541 D Ordinary Shares 2020-11-09 4 S 0 1100 192.36 D 5441 D Ordinary Shares 2020-11-09 4 S 0 800 192.55 D 4641 D Employee Stock Option (right to buy) 45.34 2020-11-09 4 M 0 1100 0.00 A 2023-05-31 Ordinary Shares 1100 0 D Employee Stock Option (right to buy) 53.52 2020-11-09 4 M 0 800 0.00 A 2024-05-30 Ordinary Shares 800 0 D Price reflects a weighted average sale price for multiple transactions ranging from $192.0701 to $192.5460 per share, inclusive. The Reporting Person undertakes to provide, upon request by the SEC Staff, the Issuer or a security holder of the Issuer, full information regarding the number of shares sold at each separate price. 2,714 of these ordinary shares are restricted. The restrictions on these ordinary shares lapse as follows: 308 on June 1, 2021; 121 on June 1, 2021; 92 on June 1, 2021; 123 on June 1, 2021; 349 on October 1, 2021; 121 on May 31, 2022; 92 on May 31, 2022; 123 on June 1, 2022; 349 on October 3, 2022; 92 on May 31, 2023; 349 on October 2, 2023; 123 on June 1, 2023; 123 on June 3, 2024; and 349 on October 1, 2024. This option to purchase 1,100 STERIS ordinary shares, which is fully vested, was received in conjunction with the Redomiciliation of the entity organized under the laws of the U.K. and formerly named STERIS plc ("Old STERIS") in exchange for an option to purchase 1,100 Old STERIS ordinary shares for $45.34 per share, subject to the same terms and conditions as the original Old STERIS stock option, except as otherwise required by law. This option to purchase 800 STERIS ordinary shares, which is fully vested, was received in conjunction with the Redomiciliation of the entity organized under the laws of the U.K. and formerly named STERIS plc ("Old STERIS") in exchange for an option to purchase 800 Old STERIS ordinary shares for $53.52 per share, subject to the same terms and conditions as the original Old STERIS stock option, except as otherwise required by law. /s/ Ronald E. Snyder, Authorized Representative under Power of Attorney 2020-11-10