144 0001585017 XXXXXXXX LIVE 0001818331 GeneDx Holdings Corp. 001-39482 333 LUDLOW STREET NORTH TOWER, 6TH FLOOR STAMFORD CT 06902 888-729-1206 Ryan Jason Director Common Merrill Lynch

2049 Century Park E Ste 1200 Los Angeles CA 90067

39222 4990000.00 28726248 08/27/2025 Nasdaq Common 12/31/2023 Open market acquisition n/a N 38072 12/31/2023 cash Common 06/18/2025 RSU Vest Issuer N 1150 08/27/2025 n/a Y 08/27/2025 Jason Ryan