<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001585017</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>


    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001818331</issuerCik>
      <issuerName>GeneDx Holdings Corp.</issuerName>
      <secFileNumber>001-39482</secFileNumber>
      <issuerAddress>
        <com:street1>333 LUDLOW STREET</com:street1>
        <com:street2>NORTH TOWER, 8TH FLOOR</com:street2>
        <com:city>STAMFORD</com:city>
        <com:stateOrCountry>CT</com:stateOrCountry>
        <com:zipCode>06902</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>617 780 8742</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Ryan Jason</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Merrill Lynch</name>
        <address>
          <com:street1>2049 Century Park E</com:street1>
          <com:street2>Ste 1200</com:street2>
          <com:city>Los Angeles</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>90067</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>47000</noOfUnitsSold>
      <aggregateMarketValue>3290000.00</aggregateMarketValue>
      <noOfUnitsOutstanding>27471397</noOfUnitsOutstanding>
      <approxSaleDate>11/19/2024</approxSaleDate>
      <securitiesExchangeName>Nasdaq</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>11/16/2023</acquiredDate>
      <natureOfAcquisitionTransaction>Open Market</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>n/a</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>47000</amountOfSecuritiesAcquired>
      <paymentDate>11/16/2023</paymentDate>
      <natureOfPayment>cash</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <noticeSignature>
      <noticeDate>11/19/2024</noticeDate>
      <signature>Jason Ryan</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
