<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001944119</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>


    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001818331</issuerCik>
      <issuerName>GeneDx Holdings Corp.</issuerName>
      <secFileNumber>001-39482</secFileNumber>
      <issuerAddress>
        <com:street1>333 LUDLOW STREET</com:street1>
        <com:street2>NORTH TOWER, 8TH FLOOR</com:street2>
        <com:city>STAMFORD</com:city>
        <com:stateOrCountry>CT</com:stateOrCountry>
        <com:zipCode>06902</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>617 780 8742</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Feeley Kevin</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Merrill Lynch</name>
        <address>
          <com:street1>2049 Century Park E</com:street1>
          <com:street2>Ste 1200</com:street2>
          <com:city>Los Angeles</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>90067</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>1430</noOfUnitsSold>
      <aggregateMarketValue>108000.00</aggregateMarketValue>
      <noOfUnitsOutstanding>27471397</noOfUnitsOutstanding>
      <approxSaleDate>01/02/2025</approxSaleDate>
      <securitiesExchangeName>Nasdaq</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>10/29/2024</acquiredDate>
      <natureOfAcquisitionTransaction>RSU vest</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>119</amountOfSecuritiesAcquired>
      <paymentDate>10/29/2024</paymentDate>
      <natureOfPayment>cashless</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>12/02/2024</acquiredDate>
      <natureOfAcquisitionTransaction>RSU vest</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>113</amountOfSecuritiesAcquired>
      <paymentDate>12/02/2024</paymentDate>
      <natureOfPayment>cashless</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>12/09/2024</acquiredDate>
      <natureOfAcquisitionTransaction>RSU vest</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>331</amountOfSecuritiesAcquired>
      <paymentDate>12/09/2024</paymentDate>
      <natureOfPayment>cashless</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>12/16/2024</acquiredDate>
      <natureOfAcquisitionTransaction>RSU vest</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>867</amountOfSecuritiesAcquired>
      <paymentDate>12/16/2024</paymentDate>
      <natureOfPayment>cashless</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Kevin Feeley</name>
        <address>
          <com:street1>333 Ludlow St</com:street1>
          <com:street2>North Tower, 6th Floor</com:street2>
          <com:city>Stamford</com:city>
          <com:stateOrCountry>CT</com:stateOrCountry>
          <com:zipCode>06902</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>10/29/2024</saleDate>
      <amountOfSecuritiesSold>274</amountOfSecuritiesSold>
      <grossProceeds>18000.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Kevin Feeley</name>
        <address>
          <com:street1>333 Ludlow St</com:street1>
          <com:street2>North Tower, 6th Floor</com:street2>
          <com:city>Stamford</com:city>
          <com:stateOrCountry>CT</com:stateOrCountry>
          <com:zipCode>06902</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>11/21/2024</saleDate>
      <amountOfSecuritiesSold>12019</amountOfSecuritiesSold>
      <grossProceeds>886000.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Kevin Feeley</name>
        <address>
          <com:street1>333 Ludlow St</com:street1>
          <com:street2>North Tower, 6th Floor</com:street2>
          <com:city>Stamford</com:city>
          <com:stateOrCountry>CT</com:stateOrCountry>
          <com:zipCode>06902</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>11/22/2024</saleDate>
      <amountOfSecuritiesSold>9981</amountOfSecuritiesSold>
      <grossProceeds>758000.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Kevin Feeley</name>
        <address>
          <com:street1>333 Ludlow St</com:street1>
          <com:street2>North Tower, 6th Floor</com:street2>
          <com:city>Stamford</com:city>
          <com:stateOrCountry>CT</com:stateOrCountry>
          <com:zipCode>06902</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>12/02/2024</saleDate>
      <amountOfSecuritiesSold>263</amountOfSecuritiesSold>
      <grossProceeds>20000.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Kevin Feeley</name>
        <address>
          <com:street1>333 Ludlow St</com:street1>
          <com:street2>North Tower, 6th Floor</com:street2>
          <com:city>Stamford</com:city>
          <com:stateOrCountry>CT</com:stateOrCountry>
          <com:zipCode>06902</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>12/09/2024</saleDate>
      <amountOfSecuritiesSold>1137</amountOfSecuritiesSold>
      <grossProceeds>87000.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Kevin Feeley</name>
        <address>
          <com:street1>333 Ludlow St</com:street1>
          <com:street2>North Tower, 6th Floor</com:street2>
          <com:city>Stamford</com:city>
          <com:stateOrCountry>CT</com:stateOrCountry>
          <com:zipCode>06902</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>12/16/2024</saleDate>
      <amountOfSecuritiesSold>3728</amountOfSecuritiesSold>
      <grossProceeds>286000.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <remarks>The sales from 10/29/24, 12/2/24, 12/9/24, and 12/16/24 reported on this form 144 represent shares sold in the past 3 months by the Reporting Person to cover tax withholding obligations in connection with the vesting and settlement of RSUs. The sales were to satisfy tax withholding obligations to be funded by a sell to cover transaction.
</remarks>
    <noticeSignature>
      <noticeDate>01/02/2025</noticeDate>
      <planAdoptionDates>
        <planAdoptionDate>08/21/2024</planAdoptionDate>
      </planAdoptionDates>
      <signature>Kevin Feeley</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
