144 0000944809 XXXXXXXX LIVE 0001818331 GeneDx Holdings Corp. 001-39482 333 LUDLOW STREET NORTH TOWER, 6TH FLOOR STAMFORD CT 06902 8887291206 OPKO HEALTH, INC. 10% Stockholder Class A Common Stock Charles Schwab & Co.

3000 Schwab Way Westlake TX 76262

13404 547955.52 26935897 09/17/2024 Nasdaq Class A Common Stock 04/29/2022 Compensation for Sale of GeneDX to Sema 4 Issuer N 13404 04/29/2022 N/a N Opko Health, INC

333 Ludlow Street, North Tower 6th Floor Stamford CT 06902

Class A Common Stock 07/01/2024 50000 1331629.33 Opko Health, INC

333 Ludlow Street, North Tower 6th Floor Stamford CT 06902

Class A Common Stock 07/02/2024 25000 728045.85 Opko Health, INC

333 Ludlow Street, North Tower 6th Floor Stamford CT 06902

Class A Common Stock 07/03/2024 14082 397427.18 Opko Health, INC

333 Ludlow Street, North Tower 6th Floor Stamford CT 06902

Class A Common Stock 07/05/2024 36118 1019956.04 Opko Health, INC

333 Ludlow Street, North Tower 6th Floor Stamford CT 06902

Class A Common Stock 07/17/2024 25000 823134.63 Opko Health, INC

333 Ludlow Street, North Tower 6th Floor Stamford CT 06902

Class A Common Stock 07/19/2024 25000 807193.41 Opko Health, INC

333 Ludlow Street, North Tower 6th Floor Stamford CT 06902

Class A Common Stock 07/22/2024 50000 1630338.88 Opko Health, INC

333 Ludlow Street, North Tower, 6th Floor Stamford CT 06902

Class A Common Stock 07/23/2024 75000 2509095.52 Opko Health, INC

333 Ludlow Street, North Tower, 6th Floor Stamford CT 06902

Class A Common Stock 07/24/2024 75000 2528928.90 Opko Health, INC

333 Ludlow Street, North Tower, 6th Floor Stamford CT 06902

Class A Common Stock 07/26/2024 60000 2031110.15 Opko Health, INC

333 Ludlow Street, North Tower, 6th Floor Stamford CT 06902

Class A Common Stock 07/29/2024 50000 1692809.79 Opko Health, INC

333 Ludlow Street, North Tower, 6th Floor Stamford CT 06902

Class A Common Stock 07/31/2024 88839 2976129.26 Opko Health, INC

333 Ludlow Street, North Tower, 6th Floor Stamford CT 06902

Class A Common Stock 08/06/2024 12994 381377.69 Opko Health, INC

333 Ludlow Street, North Tower, 6th Floor Stamford CT 06902

Class A Common Stock 08/08/2024 100000 3158971.43 Opko Health, INC

333 Ludlow Street, North Tower, 6th Floor Stamford CT 06902

Class A Common Stock 08/12/2024 59787 2029629.56 Opko Health, INC

333 Ludlow Street, North Tower, 6th Floor Stamford CT 06902

Class A Common Stock 08/13/2024 24987 868451.66 Opko Health, INC

333 Ludlow Street, North Tower, 6th Floor Stamford CT 06902

Class A Common Stock 08/15/2024 39824 1317441.91 Opko Health, INC

333 Ludlow Street, North Tower, 6th Floor Stamford CT 06902

Class A Common Stock 08/16/2024 50000 1714770.62 Opko Health, INC

333 Ludlow Street, North Tower, 6th Floor Stamford CT 06902

Class A Common Stock 08/19/2024 50000 1724437.49 Opko Health, INC

333 Ludlow Street, North Tower, 6th Floor Stamford CT 06902

Class A Common Stock 08/21/2024 94826 3270053.20 Opko Health, INC

333 Ludlow Street, North Tower, 6th Floor Stamford CT 06902

Class A Common Stock 08/22/2024 25000 851893.73 Opko Health, INC

333 Ludlow Street, North Tower, 6th Floor Stamford CT 06902

Class A Common Stock 08/23/2024 25000 884412.73 Opko Health, INC

333 Ludlow Street, North Tower, 6th Floor Stamford CT 06902

Class A Common Stock 08/26/2024 10000 348575.15 Opko Health, INC

333 Ludlow Street, North Tower, 6th Floor Stamford CT 06902

Class A Common Stock 08/26/2024 10000 348575.15 Opko Health, INC

333 Ludlow Street, North Tower, 6th Floor Stamford CT 06902

Class A Common Stock 08/29/2024 4461 147328.27 Opko Health, INC

333 Ludlow Street, North Tower, 6th Floor Stamford CT 06902

Class A Common Stock 09/04/2024 7345 232558.80 Opko Health, INC

333 Ludlow Street, North Tower, 6th Floor Stamford CT 06902

Class A Common Stock 09/09/2024 50000 1668188.68 Opko Health, INC

333 Ludlow Street, North Tower, 6th Floor Stamford CT 06902

Class A Common Stock 09/11/2024 50000 1743233.71 Opko Health, INC

333 Ludlow Street, North Tower, 6th Floor Stamford CT 06902

Class A Common Stock 09/12/2024 100000 3828672.85 Opko Health, INC

333 Ludlow Street, North Tower, 6th Floor Stamford CT 06902

Class A Common Stock 09/13/2024 8666 331769.47 Opko Health, INC

333 Ludlow Street, North Tower, 6th Floor Stamford CT 06902

Class A Common Stock 09/16/2024 50000 1878619.49 Opko Health, INC

333 Ludlow Street, North Tower, 6th Floor Stamford CT 06902

Class A Common Stock 09/17/2024 50000 1874392.75 Adam Logal is authorized agent for Opko Health Weekly volume per Yahoo Finance 9/9/24 - 1,888,400 9/2/24- 1,432,500 8/26/24- 1,710,800 8/19/24- 1,722,800 4wk avg volume LATE FILLING FOR A TRADE ON 9-17-24 09/20/2024 Adam Logal