<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <!-- Generated by Workiva -->
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001944119</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001818331</issuerCik>
      <issuerName>GeneDx Holdings Corp.</issuerName>
      <secFileNumber>001-39482</secFileNumber>
      <issuerAddress>
        <com:street1>333 Ludlow St, North Tower</com:street1>
        <com:street2>6th Floor</com:street2>
        <com:city>Stamford</com:city>
        <com:stateOrCountry>CT</com:stateOrCountry>
        <com:zipCode>06902</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>888-729-1206</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Kevin Feeley</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Class A Common Stock</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Morgan Stanley Smith Barney</name>
        <address>
          <com:street1>2000 Westchester Avenue</com:street1>
          <com:city>Purchase</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>10577</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>5805</noOfUnitsSold>
      <aggregateMarketValue>625400</aggregateMarketValue>
      <noOfUnitsOutstanding>28726248</noOfUnitsOutstanding>
      <approxSaleDate>09/30/2025</approxSaleDate>
      <securitiesExchangeName>NASDAQ</securitiesExchangeName>
    </securitiesInformation>
    <securitiesInformation>
      <securitiesClassTitle>Class A Common Stock</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Merrill Lynch</name>
        <address>
          <com:street1>2049 Century Park E</com:street1>
          <com:street2>Ste 1200</com:street2>
          <com:city>Los Angeles</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>90067</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>6609</noOfUnitsSold>
      <aggregateMarketValue>716260</aggregateMarketValue>
      <noOfUnitsOutstanding>28726248</noOfUnitsOutstanding>
      <approxSaleDate>09/30/2025</approxSaleDate>
      <securitiesExchangeName>NASDAQ</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Class A Common Stock</securitiesClassTitle>
      <acquiredDate>05/02/2022</acquiredDate>
      <natureOfAcquisitionTransaction>Acquired as compensation - Restricted Stock Units</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>758</amountOfSecuritiesAcquired>
      <paymentDate>05/02/2022</paymentDate>
      <natureOfPayment>Compensation</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Class A Common Stock</securitiesClassTitle>
      <acquiredDate>09/01/2022</acquiredDate>
      <natureOfAcquisitionTransaction>Acquired as compensation - Restricted Stock Units</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>713</amountOfSecuritiesAcquired>
      <paymentDate>09/01/2022</paymentDate>
      <natureOfPayment>Compensation</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Class A Common Stock</securitiesClassTitle>
      <acquiredDate>09/01/2022</acquiredDate>
      <natureOfAcquisitionTransaction>Acquired as compensation - Stock Options</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>1246</amountOfSecuritiesAcquired>
      <paymentDate>09/01/2022</paymentDate>
      <natureOfPayment>Compensation</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Class A Common Stock</securitiesClassTitle>
      <acquiredDate>12/09/2022</acquiredDate>
      <natureOfAcquisitionTransaction>Acquired as compensation - Restricted Stock Units</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>2474</amountOfSecuritiesAcquired>
      <paymentDate>12/09/2022</paymentDate>
      <natureOfPayment>Compensation</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Class A Common Stock</securitiesClassTitle>
      <acquiredDate>04/26/2023</acquiredDate>
      <natureOfAcquisitionTransaction>Acquired as compensation - Restricted Stock Units</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>7223</amountOfSecuritiesAcquired>
      <paymentDate>04/26/2023</paymentDate>
      <natureOfPayment>Compensation</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Kevin Feeley</name>
        <address>
          <com:street1>333 Ludlow St, North Tower</com:street1>
          <com:street2>6th Floor</com:street2>
          <com:city>Stamford</com:city>
          <com:stateOrCountry>CT</com:stateOrCountry>
          <com:zipCode>06902</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Class A Common Stock</securitiesClassTitle>
      <saleDate>07/01/2025</saleDate>
      <amountOfSecuritiesSold>1344</amountOfSecuritiesSold>
      <grossProceeds>122471</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Kevin Feeley</name>
        <address>
          <com:street1>333 Ludlow St, North Tower</com:street1>
          <com:street2>6th Floor</com:street2>
          <com:city>Stamford</com:city>
          <com:stateOrCountry>CT</com:stateOrCountry>
          <com:zipCode>06902</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Class A Common Stock</securitiesClassTitle>
      <saleDate>07/09/2025</saleDate>
      <amountOfSecuritiesSold>5278</amountOfSecuritiesSold>
      <grossProceeds>490854</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Kevin Feeley</name>
        <address>
          <com:street1>333 Ludlow St, North Tower</com:street1>
          <com:street2>6th Floor</com:street2>
          <com:city>Stamford</com:city>
          <com:stateOrCountry>CT</com:stateOrCountry>
          <com:zipCode>06902</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Class A Common Stock</securitiesClassTitle>
      <saleDate>07/29/2025</saleDate>
      <amountOfSecuritiesSold>388</amountOfSecuritiesSold>
      <grossProceeds>40860</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Kevin Feeley</name>
        <address>
          <com:street1>333 Ludlow St, North Tower</com:street1>
          <com:street2>6th Floor</com:street2>
          <com:city>Stamford</com:city>
          <com:stateOrCountry>CT</com:stateOrCountry>
          <com:zipCode>06902</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Class A Common Stock</securitiesClassTitle>
      <saleDate>09/02/2025</saleDate>
      <amountOfSecuritiesSold>378</amountOfSecuritiesSold>
      <grossProceeds>47556</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Kevin Feeley</name>
        <address>
          <com:street1>333 Ludlow St, North Tower</com:street1>
          <com:street2>6th Floor</com:street2>
          <com:city>Stamford</com:city>
          <com:stateOrCountry>CT</com:stateOrCountry>
          <com:zipCode>06902</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Class A Common Stock</securitiesClassTitle>
      <saleDate>09/09/2025</saleDate>
      <amountOfSecuritiesSold>1272</amountOfSecuritiesSold>
      <grossProceeds>162886</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Kevin Feeley</name>
        <address>
          <com:street1>333 Ludlow St, North Tower</com:street1>
          <com:street2>6th Floor</com:street2>
          <com:city>Stamford</com:city>
          <com:stateOrCountry>CT</com:stateOrCountry>
          <com:zipCode>06902</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Class A Common Stock</securitiesClassTitle>
      <saleDate>09/16/2025</saleDate>
      <amountOfSecuritiesSold>3728</amountOfSecuritiesSold>
      <grossProceeds>452840</grossProceeds>
    </securitiesSoldInPast3Months>
    <remarks>Represents approximately 12,414 shares to be sold on behalf of the Reporting Person, including 1) approximately 393 shares to be sold in connection with the anticipated vesting of RSUs on October 29, 2025; 2) approximately 374 shares to be sold in connection with the anticipated vesting of RSUs on December 1, 2025; 3) approximately 1,284 shares to be sold in connection with the anticipated vesting of RSUs on December 9, 2025; 4) approximately 3,754 shares to be sold in connection with the anticipated vesting of RSUs on December 16, 2025; and 5) 6,609 shares to be sold by the Reporting Person pursuant to the Reporting Person's Rule 10b5-1 trading plan adopted on August 21, 2024. Shares sold in the past 3 months by the Reporting Person include: 1) 5,766 shares sold to cover tax withholding obligations in connection with the vesting and settlement of RSUs; and 2) 6,622 shares in connection with sales pursuant to the Reporting Person's Rule 10b5-1 trading plan adopted on August 21, 2024.</remarks>
    <noticeSignature>
      <noticeDate>09/30/2025</noticeDate>
      <planAdoptionDates>
        <planAdoptionDate>08/21/2024</planAdoptionDate>
      </planAdoptionDates>
      <signature>/s/ Kevin Feeley</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
