144 0001944119 XXXXXXXX LIVE 0001818331 GeneDx Holdings Corp. 001-39482 333 Ludlow St, North Tower 6th Floor Stamford CT 06902 888-729-1206 Kevin Feeley Officer Class A Common Stock Morgan Stanley Smith Barney

2000 Westchester Avenue Purchase NY 10577

5805 535900 28723440 07/01/2025 NASDAQ Class A Common Stock Merrill Lynch

2049 Century Park E Ste 1200 Los Angeles CA 90067

6622 613300 28723440 07/01/2025 NASDAQ Class A Common Stock 05/02/2022 Restricted Stock Unit Granted Issuer N 365 05/02/2022 N/A Class A Common Stock 09/01/2022 Restricted Stock Unit Granted Issuer N 348 09/01/2022 N/A Class A Common Stock 09/01/2022 Stock Option Granted Issuer N 1245 09/01/2022 N/A Class A Common Stock 12/09/2022 Restricted Stock Unit Granted Issuer N 1196 12/09/2022 N/A Class A Common Stock 04/26/2023 Restricted Stock Unit Granted Issuer N 3468 04/26/2023 N/A Class A Common Stock 05/02/2022 Restricted Stock Unit Granted Issuer N 393 05/02/2022 N/A Class A Common Stock 09/01/2022 Restricted Stock Unit Granted Issuer N 374 09/01/2022 N/A Class A Common Stock 12/09/2022 Restricted Stock Unit Granted Issuer N 1284 12/09/2022 N/A Class A Common Stock 04/26/2023 Restricted Stock Unit Granted Issuer N 3754 04/26/2023 N/A N Kevin Feeley

333 Ludlow St, North Tower 6th Floor Stamford CT 06902

Class A Common Stock 04/09/2025 14270 1313700 Kevin Feeley

333 Ludlow St, North Tower 6th Floor Stamford CT 06902

Class A Common Stock 04/29/2025 388 43900 Kevin Feeley

333 Ludlow St, North Tower 6th Floor Stamford CT 06902

Class A Common Stock 06/02/2025 370 26400 Kevin Feeley

333 Ludlow St, North Tower 6th Floor Stamford CT 06902

Class A Common Stock 06/09/2025 1266 91800 Kevin Feeley

333 Ludlow St, North Tower 6th Floor Stamford CT 06902

Class A Common Stock 06/16/2025 3729 241500 Represents 12,427 shares to be sold on behalf of the Reporting Person, including 1) 393 shares to be sold in connection with the anticipated vesting of RSUs on July 29, 2025; 2) 374 shares to be sold in connection with the anticipated vesting of RSUs on September 1, 2025; 3) 1,284 shares to be sold in connection with the anticipated vesting of RSUs on September 9, 2025; 4) 3,754 shares to be sold in connection with the anticipated vesting of RSUs on September 16, 2025; and 5) 6,622 shares to be sold by the Reporting Person pursuant to the Reporting Person's Rule 10b5-1 trading plan adopted on August 21, 2024. Shares sold in the past 3 months by the Reporting Person include: 1) 5,753 shares sold to cover tax withholding obligations in connection with the vesting and settlement of RSUs; and 2) 14,270 shares in connection with sales pursuant to the Reporting Person's Rule 10b5-1 trading plan adopted on August 21, 2024. 07/01/2025 08/21/2024 /s/ Kevin Feeley