144 0001944119 XXXXXXXX LIVE 0001818331 GeneDx Holdings Corp. 001-39482 333 Ludlow St, North Tower 6th Floor Stamford CT 06902 888-729-1206 Kevin Feeley Officer Class A Common Stock Morgan Stanley Smith Barney

2000 Westchester Avenue Purchase NY 10577-2530

370 26400 28579934 06/02/2025 NASDAQ Class A Common Stock 06/01/2025 Restricted Stock Unit Vest Issuer N 370 06/01/2025 N/A N Kevin Feeley

333 Ludlow St, North Tower 6th Floor Stamford CT 06902

Class A Common Stock 03/03/2025 261 27100 Kevin Feeley

333 Ludlow St, North Tower 6th Floor Stamford CT 06902

Class A Common Stock 03/10/2025 922 87300 Kevin Feeley

333 Ludlow St, North Tower 6th Floor Stamford CT 06902

Class A Common Stock 03/13/2025 402 36200 Kevin Feeley

333 Ludlow St, North Tower 6th Floor Stamford CT 06902

Class A Common Stock 03/17/2025 3749 362600 Kevin Feeley

333 Ludlow St, North Tower 6th Floor Stamford CT 06902

Class A Common Stock 03/26/2025 8746 836200 Kevin Feeley

333 Ludlow St, North Tower 6th Floor Stamford CT 06902

Class A Common Stock 04/09/2025 14270 1313700 Kevin Feeley

333 Ludlow St, North Tower 6th Floor Stamford CT 06902

Class A Common Stock 04/29/2025 388 43900 Represents 370 shares to be sold on behalf of the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units, and shares sold in the past 3 months by the Reporting Person, including: 1) 14,468 shares sold to cover tax withholding obligations in connection with the vesting and settlement of RSUs; and 2) 14,270 shares in connection with sales pursuant to the Reporting Person's Rule 10b5-1 trading plan adopted on August 21, 2024. 06/02/2025 /s/ Kevin Feeley