144 0001944119 XXXXXXXX LIVE 0001818331 GeneDx Holdings Corp. 001-39482 333 Ludlow St, North Tower 6th Floor Stamford CT 06902 888-729-1206 Kevin Feeley Officer Class A Common Stock Morgan Stanley Smith Barney

2000 Westchester Avenue Purchase NY 10577-2530

402 36200 28244306 03/13/2025 NASDAQ Class A Common Stock 03/09/2025 Restricted Stock Unit Vest Issuer N 402 03/09/2025 N/A N Kevin Feeley

333 Ludlow St, North Tower 6th Floor Stamford CT 06902

Class A Common Stock 12/16/2024 3728 286100 Kevin Feeley

333 Ludlow St, North Tower 6th Floor Stamford CT 06902

Class A Common Stock 01/02/2025 1430 108700 Kevin Feeley

333 Ludlow St, North Tower 6th Floor Stamford CT 06902

Class A Common Stock 01/07/2025 35506 3331000 Kevin Feeley

333 Ludlow St, North Tower 6th Floor Stamford CT 06902

Class A Common Stock 01/29/2025 275 21600 Kevin Feeley

333 Ludlow St, North Tower 6th Floor Stamford CT 06902

Class A Common Stock 03/03/2025 261 27100 Kevin Feeley

333 Ludlow St, North Tower 6th Floor Stamford CT 06902

Class A Common Stock 03/10/2025 922 87300 Represents 402 shares to be sold on behalf of the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units, and shares sold in the past 3 months by the Reporting Person, including: 1) 5,186 shares sold to cover tax withholding obligations in connection with the vesting and settlement of RSUs; and 2) 36,936 shares in connection with sales pursuant to the Reporting Person's Rule 10b5-1 trading plan adopted on August 21, 2024. 03/13/2025 /s/ Kevin Feeley