<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <!-- Generated by Workiva -->
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001944119</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001818331</issuerCik>
      <issuerName>GeneDx Holdings Corp.</issuerName>
      <secFileNumber>001-39482</secFileNumber>
      <issuerAddress>
        <com:street1>333 Ludlow St, North Tower</com:street1>
        <com:street2>6th Floor</com:street2>
        <com:city>Stamford</com:city>
        <com:stateOrCountry>CT</com:stateOrCountry>
        <com:zipCode>06902</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>888-729-1206</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Kevin Feeley</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Class A Common Stock</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Morgan Stanley Smith Barney</name>
        <address>
          <com:street1>2000 Westchester Avenue</com:street1>
          <com:city>Purchase</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>10577-2530</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>261</noOfUnitsSold>
      <aggregateMarketValue>27100</aggregateMarketValue>
      <noOfUnitsOutstanding>28235298</noOfUnitsOutstanding>
      <approxSaleDate>03/03/2025</approxSaleDate>
      <securitiesExchangeName>NASDAQ</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Class A Common Stock</securitiesClassTitle>
      <acquiredDate>03/03/2025</acquiredDate>
      <natureOfAcquisitionTransaction>Restricted Stock Unit Vest</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>261</amountOfSecuritiesAcquired>
      <paymentDate>03/03/2025</paymentDate>
      <natureOfPayment>N/A</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Kevin Feeley</name>
        <address>
          <com:street1>333 Ludlow St, North Tower</com:street1>
          <com:street2>6th Floor</com:street2>
          <com:city>Stamford</com:city>
          <com:stateOrCountry>CT</com:stateOrCountry>
          <com:zipCode>06902</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Class A Common Stock</securitiesClassTitle>
      <saleDate>12/09/2024</saleDate>
      <amountOfSecuritiesSold>1137</amountOfSecuritiesSold>
      <grossProceeds>86800</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Kevin Feeley</name>
        <address>
          <com:street1>333 Ludlow St, North Tower</com:street1>
          <com:street2>6th Floor</com:street2>
          <com:city>Stamford</com:city>
          <com:stateOrCountry>CT</com:stateOrCountry>
          <com:zipCode>06902</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Class A Common Stock</securitiesClassTitle>
      <saleDate>12/16/2024</saleDate>
      <amountOfSecuritiesSold>3728</amountOfSecuritiesSold>
      <grossProceeds>286100</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Kevin Feeley</name>
        <address>
          <com:street1>333 Ludlow St, North Tower</com:street1>
          <com:street2>6th Floor</com:street2>
          <com:city>Stamford</com:city>
          <com:stateOrCountry>CT</com:stateOrCountry>
          <com:zipCode>06902</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Class A Common Stock</securitiesClassTitle>
      <saleDate>01/02/2025</saleDate>
      <amountOfSecuritiesSold>1430</amountOfSecuritiesSold>
      <grossProceeds>108700</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Kevin Feeley</name>
        <address>
          <com:street1>333 Ludlow St, North Tower</com:street1>
          <com:street2>6th Floor</com:street2>
          <com:city>Stamford</com:city>
          <com:stateOrCountry>CT</com:stateOrCountry>
          <com:zipCode>06902</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Class A Common Stock</securitiesClassTitle>
      <saleDate>01/07/2025</saleDate>
      <amountOfSecuritiesSold>35506</amountOfSecuritiesSold>
      <grossProceeds>3331000</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Kevin Feeley</name>
        <address>
          <com:street1>333 Ludlow St, North Tower</com:street1>
          <com:street2>6th Floor</com:street2>
          <com:city>Stamford</com:city>
          <com:stateOrCountry>CT</com:stateOrCountry>
          <com:zipCode>06902</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Class A Common Stock</securitiesClassTitle>
      <saleDate>01/29/2025</saleDate>
      <amountOfSecuritiesSold>275</amountOfSecuritiesSold>
      <grossProceeds>21600</grossProceeds>
    </securitiesSoldInPast3Months>
    <remarks>Represents 261 shares to be sold on behalf of the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units, and shares sold in the past 3 months by the Reporting Person, including: 1) 5,140 shares sold to cover tax withholding obligations in connection with the vesting and settlement of RSUs to satisfy tax withholding obligations to be funded by a sell to cover transaction; and 2) 36,936 shares in connection with sales pursuant to the Reporting Persons Rule 10b5-1 trading plan adopted on August 16, 2024.</remarks>
    <noticeSignature>
      <noticeDate>03/03/2025</noticeDate>
      <signature>/s/ Kevin Feeley</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
