144 0001944119 XXXXXXXX LIVE 0001818331 GeneDx Holdings Corp. 001-39482 333 Ludlow St, North Tower 6th Floor Stamford CT 06902 888-729-1206 Kevin Feeley Officer Class A Common Stock Morgan Stanley Smith Barney 2000 Westchester Avenue Purchase NY 10577 5410 458500 29822541 09/01/2026 NASDAQ Class A Common Stock 09/01/2022 Acquired as compensation - Restricted Stock Units Issuer N 372 09/01/2022 Compensation Class A Common Stock 12/09/2022 Acquired as compensation - Restricted Stock Units Issuer N 1284 12/09/2022 Compensation Class A Common Stock 04/26/2023 Acquired as compensation - Restricted Stock Units Issuer N 3754 04/26/2023 Compensation N Kevin Feeley 333 Ludlow St, North Tower 6th Floor Stamford CT 06902 Class A Common Stock 06/01/2026 369 19092 Kevin Feeley 333 Ludlow St, North Tower 6th Floor Stamford CT 06902 Class A Common Stock 06/09/2026 1266 68073 Kevin Feeley 333 Ludlow St, North Tower 6th Floor Stamford CT 06902 Class A Common Stock 06/16/2026 3729 226597 Represents approximately 5,410 shares to be sold on behalf of the Reporting Person, including 1) 372 shares to be sold in connection with anticipated vesting of RSUs on September 1, 2026; 2) approximately 1,284 shares to be sold in connection with anticipated vesting of RSUs on September 9, 2026; and 3) approximately 3,754 shares to be sold in connection with anticipated vesting of RSUs on September 16, 2026. Shares sold in the past 3 months by the Reporting Person include 5,364 shares sold to cover tax withholding obligations in connection with vesting and settlement of RSUs. 09/01/2026 /s/ Kevin Feeley