144 0001689575 XXXXXXXX LIVE 0001818331 GeneDx Holdings Corp. 001-39482 333 Ludlow St, North Tower 6th Floor Stamford CT 06902 888-729-1206 Katherine Stueland Officer Director Class A Common Stock Morgan Stanley Smith Barney 2000 Westchester Avenue Purchase NY 10577 14243 1208100 29822541 09/09/2026 NASDAQ Class A Common Stock 12/09/2022 Acquired as compensation - Restricted Stock Units Issuer N 3686 12/09/2022 Compensation Class A Common Stock 04/26/2023 Acquired as compensation - Restricted Stock Units Issuer N 10557 04/26/2023 Compensation N Katherine Stueland 333 Ludlow St, North Tower 6th Floor Stamford CT 06902 Class A Common Stock 06/09/2026 3639 195669 Katherine Stueland 333 Ludlow St, North Tower 6th Floor Stamford CT 06902 Class A Common Stock 06/16/2026 10501 638104 Represents approximately 14,243 shares to be sold on behalf of the Reporting Person, including 1) approximately 3,686 shares to be sold in connection with anticipated vesting of RSUs on September 9, 2026; and 2) approximately 10,557 shares to be sold in connection with anticipated vesting of RSUs on September 16, 2026. Shares sold in the past 3 months by the Reporting Person include 14,140 shares sold to cover tax withholding obligations in connection with vesting and settlement of RSUs. 09/01/2026 /s/ Katherine Stueland