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Income Taxes - Reconciliation of Effective Tax Rate (Details)
12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Income Tax Disclosure [Abstract]      
U.S. federal taxes at statutory rate 21.00% 21.00% 21.00%
State taxes (net of federal benefit) 10.50% 2.10% 3.50%
Research and development tax credits 0.70% 0.60% 3.40%
Non-deductible stock-based compensation (11.30%) (7.80%) (3.30%)
162(m) Limitation (0.057) 0 0
Permanent Items (0.20%) 0.00% (0.50%)
Unrealized fair market value gain on warrants 17.00% 0.00% 0.00%
Change in valuation allowance (32.00%) (15.90%) (24.10%)
Effective tax rate 0.00% 0.00% 0.00%