144 0001535472 XXXXXXXX LIVE 0001818331 GeneDx Holdings Corp. 001-39482 333 Ludlow Street, North Tower, 6th Floor Stamford CT 06902 800-298-6470 Corvex Management LP on behalf of Corvex Master Fund LP and Corvex Select Equity Master Fund(1) Affiliate Class A common stock, $0.0001 par value per share(2) Goldman Sachs & Co. LLC

200 West Street New York NY 10282

833742 1075527.00 25884279 11/15/2023 Nasdaq Global Select Class A common stock, $0.0001 par value per share 07/22/2021 Purchase from Issuer(3) GeneDx Holdings Corp. N 21324 07/22/2021 cash Class A common stock, $0.0001 par value per share 04/29/2022 Purchase from Issuer(3) GeneDx Holdings Corp. N 221818 04/29/2022 cash Class A common stock, $0.0001 par value per share 02/01/2023 Purchase from Issuer(3) GeneDx Holdings Corp. N 590600 02/01/2023 cash Y 1. Corvex Management LP is deemed to be the beneficial owner of the shares of Class A common stock ("Common Stock") of GeneDx Holdings Corp. (the "Issuer") held by Corvex Master Fund LP and Corvex Select Equity Master Fund. 2. Includes 590,600 shares of Common Stock held by Corvex Master Fund LP and 243,142 shares of Common Stock held by Corvex Select Equity Master Fund LP. 3. Share amounts have been adjusted to reflect the impact of a 1-for-33 reverse stock split of the Issuer's Common Stock that became effective on May 4, 2023. 11/15/2023 /s/ Patrick Dooley, authorized signatory of Corvex Management LP