X0508 4 2024-01-11 0 0001818331 GeneDx Holdings Corp. WGS 0001585017 Ryan Jason C/O GENEDX HOLDINGS CORP. 333 LUDLOW ST, NORTH TOWER STAMFORD CT 06902 1 0 0 0 0 Class A Common Stock 2024-01-11 4 G 0 73614 0.00 D 0 D Class A Common Stock 188356 I By Jason Ryan Trust u/a dtd 11/25/2018 On January 11, 2024, the reporting person transferred 73,614 shares of GeneDx Holdings Corp. Class A common stock to the Jason Ryan Trust u/a dtd 11/25/2018 for no consideration. The reporting person is the trustee of the trust, and the reporting person and his spouse are the sole beneficiaries of the trust. /s/ Devin Schaffer, Attorney-in-Fact 2024-01-12