X0508 4 2023-11-16 0 0001818331 GeneDx Holdings Corp. WGS 0001585017 Ryan Jason C/O GENEDX HOLDINGS CORP. 333 LUDLOW ST, NORTH TOWER STAMFORD CT 06902 1 1 0 0 Executive Chairman 0 Class A Common Stock 2023-11-16 4 P 0 56742 1.2722 A 56742 I By Jason Ryan Trust u/a dtd 11/25/2018 Class A Common Stock 2023-11-17 4 P 0 58000 1.5376 A 114742 I By Jason Ryan Trust u/a dtd 11/25/2018 Class A Common Stock 5834 D The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $1.175 to $1.395, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth herein. The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $1.41 to $1.61, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth herein. /s/ Devin Schaffer, Attorney-in-Fact 2023-11-20