X0407 4 2023-07-01 0 0001818331 GeneDx Holdings Corp. WGS 0001874118 White Karen Ann C/O GENEDX HOLDINGS CORP. 333 LUDLOW ST, NORTH TOWER, 6TH FL. STAMFORD CT 06902 0 1 0 0 Chief People Officer 0 Class A Common Stock 2023-07-01 4 M 0 99 A 4730 D Class A Common Stock 2023-07-03 4 S 0 45 5.99 D 4685 D Restricted Stock Unit 2023-07-01 4 M 0 99 0.00 D Class A Common Stock 99 1092 D Each restricted stock unit ("RSU") represents a contingent right to receive 1 share of the Issuer's Class A Common Stock upon settlement for no consideration. The sale reported on this Form 4 represents shares sold by the Reporting Person to cover tax withholding obligations in connection with the vesting and settlement of RSUs. The sale was to satisfy tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary transaction by the Reporting Person. 6.25% vest in quarterly installments over the 4-year period commencing on April 4, 2022 until fully vested, subject to the Reporting Person's continued service to the Issuer on each vesting date /s/ Devin Schaffer, Attorney-in-Fact 2023-07-05